A New Antibiotic Prophylaxis Regimen to Prevent Bacteremia Following Dental Procedures

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to evaluate the efficacy of prophylactic dosage with amoxicillin (AMX), amoxicillin-clavulanate (AMX-CLV), and a combination of amoxicillin-clavulanate and a chlorhexidine mouthwash (AMX-CLV-CHX) in the prevention of bacteremia following dental extractions.

The study hypothesis is that an antimicrobial regimen with amoxicillin-clavulanate will show higher effectiveness in reducing the prevalence and duration of bacteremia following dental extractions, than that achieved with the classical amoxicillin regimen.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Santiago de Compostela
• Collaborator: Hospital Clinico Universitario de Santiago
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chlorhexidine; Chlorhexidine gluconate; Clavulanic Acid; Clavulanic Acids; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• Subjects must have at least 10 teeth

• Subjects must have the need for a dental extraction under general anesthesia (for behavioral reasons)

• Subjects will be recruited regardless of the extent and severity of their dental and/or periodontal disease

Exclusion Criteria:

• Age under 18 years

• Body weight under 40 kg

• Receipt of antibiotics in the previous 3 months

• Routine use of oral antiseptics

• A history of allergy or intolerance to amoxicillin

• A history of allergy or intolerance to chlorhexidine

• A history of allergy or intolerance to amoxicillin-clavulanate

• Any type of congenital or acquired immunodeficiency

• Any known risk factor for bacterial endocarditis

• Any known risk factor for prolonged bleeding