A Multiple-Dose Study of BLU-5937 in Chronic Pruritus Associated With Atopic Dermatitis

• Status: Recruiting
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a multicenter, randomized, double-blind, placebo-controlled, parallel design study of BLU-5937 for the treatment of chronic pruritus in adult subjects with atopic dermatitis (AD).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bellus Health Inc

Criteria

Inclusion Criteria:

• Willing to participate and is capable of giving informed consent

• Clinically confirmed diagnosis of active AD with at least a 6-month history of AD

• Chronic pruritus related to AD for at least 3 months

• Moderate to severe itch associated with mild to moderate AD

• Female of childbearing potential must agree to use a highly effective contraceptive method during the study and until at least 4 weeks after the last study drug administration

Exclusion Criteria:

• History of skin disease or presence of skin condition that would interfere with the study assessments

• Clearly defined etiology for pruritus other than AD, including but not limited to:

urticaria, psoriasis, or other non-atopic dermatologic conditions, hepatic or renal disease, psychogenic pruritus, drug reaction, uncontrolled hyperthyroidism, and infection

• Presence of any acute skin condition other than AD which may risk inducing a pruritus flare/worsening during the course of the study, including but not limited to: impetigo, active herpes simplex infection, or allergic contact dermatitis

• Subject is >65 years of age and has developed pruritus at age of ≥50 years

• History of cancer or lymphoproliferative disease within 5 years with the exception of successfully treated nonmetastatic cutaneous squamous cell or basal cell carcinoma and/or localized carcinoma in situ of the cervix

• Known history of, or active, parasitic infection, including skin parasites such as scabies within 12 months prior to Screening

• Known history of chronic infectious disease (e.g. hepatitis B, hepatitis C, or human immunodeficiency virus [HIV])

• Known history of clinically significant drug or alcohol abuse in the last year

• Previous participation in a BLU-5937 trial