A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma
Status:
Unknown status
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
The trial is an investigator-driven research study in subjects with intermittent asthma, the
aim of which is to explore the likelihood of a functionally important separate leukotriene E4
(LTE4) receptor in airways and/or inflammatory cells in human subjects with asthma.
Mostly on the basis of experiments in mice models, the prevailing view suggests that the
present class of anti-leukotriene drugs are insufficient because they do not block the
pro-inflammatory and bronchoconstrictive effects of LTE4. It is established by us and other
groups that LTE4 is the most stable and long-lived leukotriene.
The study will establish the effect of oral treatment with the highly selective
CysLT1-receptor antagonist, montelukast, on bronchial responsiveness to inhaled LTE4 in
subjects with intermittent asthma