A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin

• Status: Completed
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this project is to study the role of transient receptor potential (TRP-) channel V1 (TRPV1+) fibers in the development of cutaneous inflammation induced by epidermal Ultraviolet-B damage. Moreover, in this project the investigators want to evaluate if the capsaicin-desensitization action can still be induced in a skin area pretreated with topical, local anesthetic lidocaine.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aalborg University
• Treatments: Capsaicin; Histamine; Histamine phosphate; Lidocaine

Criteria

Inclusion criteria:

• Healthy men and women

• 18-60 years

• Caucasian descent (only in sub-study 1)

• Speak and understand English

Exclusion criteria:

• Pregnancy or lactation

• Drug addiction defined as any use of cannabis, opioids or other drugs

• Previous or current neurologic, musculoskeletal or mental illnesses

• Lack of ability to cooperate

• Current use of medications that may affect the trial

• Skin diseases

• Consumption of alcohol or painkillers 24 hours before the study days and between these

• Moles or tattoos in the area to be treated or tested.

• Exposure of the irradiated area to UV radiation (e.g., sun) 48 hours before the study days and between these

• Acute or chronic pain

• Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)

• Known history of anaphylactic shock, or local allergy (contact dermatitis) to lidocaine, prilocaine or other local anaesthetics of the amide type.