A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing

• Status: Completed
• Trial end date: 2019-08-28
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch. Moreover, the purpose is to evaluate the effect of mild pre-heating of the skin in human experimental models of histamine, cowhage and serotonin. Finally, we want to investigate the effect of short-term intense heat stimulation on previously anesthetized skin.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aalborg University
• Treatments: Histamine; Histamine phosphate; Lidocaine; Serotonin

Criteria

Inclusion Criteria:

• Healthy men and women

• Age 18-60 years

• Able to speak and understand English

Exclusion Criteria:

• Suffering from chronic disease

• Pregnancy or lactation

• Prior experience of adverse effects from anaesthetic, specifically Lidocaine

• Drug addiction defined as the use of cannabis, opioids or other drugs - 5 -

• Previous neurologic, musculoskeletal or mental illnesses

• Lack of ability to cooperate

• Current use of medications that may affect the trial

• Active skin diseases

• Active participation in other experiments currently ongoing or within the last 14 days

• Tattoos on volar forearms that will interfere with local skin measurements