A Low ChloridE hyperTonic Solution for Brain Edema

• Status: Completed
• Trial end date: 2018-09-30
• Target enrollment: 0
• Participant gender: All

Summary

This pilot study will compare the two hypertonic solutions currently used for subarachnoid hemorrhage (SAH) - related complications and to determine if the reduction of chloride load is safer, and as efficacious as the classic hypertonic solution.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Emory University
• Treatments: Pharmaceutical Solutions; Plasma-lyte 148

Criteria

Inclusion Criteria:

• Spontaneous SAH with an identified aneurysmal source as identified on neuroimaging obtained at admission to Emory University Hospital or with imaging at an outside hospital

• Age ≥ 18 years

Exclusion Criteria:

• SAH related to non-aneurysmal vascular anomaly

• SAH thought due to trauma

• SAH occurring in relation to another medical procedure (cardiac catheterization, LVAD placement, etc.)

• SAH with a negative workup for cause ("angio-negative")

• Patients who arrive in a brain-death state or in a devastating clinical status that will be presumed to lead to brain death or early withdrawal of treatment

• Patient who suffer from end-stage renal disease at baseline and who are routinely treated with dialysis

• Known pregnancy