Overview A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD) Status: Terminated Trial end date: 2020-05-01 Target enrollment: Participant gender: Summary This study will assess the long-term safety and tolerability of ALKS 5461 as an adjunctive treatment for refractory MDD. Phase: Phase 3 Details Lead Sponsor: Alkermes, Inc.