Overview

A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma

Status:
Active, not recruiting
Trial end date:
2026-01-15
Target enrollment:
Participant gender:
Summary
This open-label, randomized, 2-arm, multicenter, phase 3 study has the primary objective of comparing the modified progression-free survival (mPFS) obtained with brentuximab vedotin (ADCETRIS®) plus AVD (doxorubicin [Adriamycin], vinblastine, and dacarbazine; abbreviated A+AVD) versus that obtained with ABVD (doxorubicin [Adriamycin],bleomycin, vinblastine, and dacarbazine) for the frontline treatment of advanced classical Hodgkin lymphoma(HL)
Phase:
Phase 3
Details
Lead Sponsor:
Millennium Pharmaceuticals, Inc.
Collaborators:
Seagen Inc.
Seattle Genetics, Inc.
Treatments:
Antibodies
Antibodies, Monoclonal
Bleomycin
Brentuximab Vedotin
Dacarbazine
Doxorubicin
Liposomal doxorubicin
Vinblastine