A Feasibility Study of N-acetylcysteine for Self-injurious Behavior in Children With Autism Spectrum Disorder
Status:
Completed
Trial end date:
2019-09-12
Target enrollment:
Participant gender:
Summary
The purpose of this study is to demonstrate the feasibility of a 9-week, randomized trial of
N-acetylcysteine (NAC) compared to placebo in 14 children (age 5 to 12 years) with Autism
Spectrum Disorder (ASD) and a moderate level of repetitive self-injurious behavior (SIB).
Additional aims are to evaluate the positive predictive value of a screening method to
classify children with automatically maintained self-injurious behavior; to evaluate the
preliminary efficacy of NAC for reducing repetitive SIB in children with ASD; and to evaluate
biomarkers and possible mechanisms of action of NAC in children with ASD.