Overview

A Drug Interaction Study With Fluticasone Furoate/GW642444 Inhalation Powder and Ketoconazole

Status:
Completed
Trial end date:
2010-08-28
Target enrollment:
0
Participant gender:
All
Summary
A randomized two-way crossover study to determine whether concomitant administration of CYP P450 3A4 inhibitor ketoconazole and fluticasone furoate/GW642444M combination significantly increases the systemic effects and exposure to repeat dose fluticasone furoate and/or GW642444 in healthy subjects. Key assessments will include blood potassium, heart rate, blood pressure, QTc, serum cortisol and pharmacokinetic parameters, and safety including vital signs, ECGs, adverse event monitoring and laboratory safety tests, including blood glucose.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
GlaxoSmithKline
Treatments:
Fluticasone
Ketoconazole
Criteria
Inclusion Criteria:

1. Healthy male or female between 18 and 64 years of age inclusive

2. A female subject is eligible to participate if she is of:

- Non-childbearing potential defined as pre-menopausal females with a documented
tubal ligation or hysterectomy; or postmenopausal defined as 12 months of
spontaneous amenorrhea [in questionable cases a blood sample with simultaneous
follicle stimulating hormone (FSH) > 40 MlU/ml and estradiol < 40 pg/ml (<140
pmol/L) is confirmatory]. Females on hormone replacement therapy (HRT) and whose
menopausal status is in doubt will be required to use one of the contraception
methods in Section 8.1 if they wish to continue their HRT during the study.
Otherwise, they must discontinue HRT to allow confirmation of post-menopausal
status prior to study enrollment. For most forms of HRT, at least 2-4 weeks will
elapse between the cessation of therapy and the blood draw; this interval depends
on the type and dosage of HRT. Following confirmation of their post-menopausal
status, they can resume use of HRT during the study without use of a
contraceptive method.

- Child-bearing potential and agrees to use one of the contraception methods listed
in Section 8.1 for an appropriate period of time (as determined by the product
label or investigator) prior to the start of dosing to sufficiently minimize the
risk of pregnancy at that point. Female subjects must agree to use contraception
until completion of the follow-up visit.

3. Body mass index within range of 18.5-29.0 kg/m2 inclusive.

4. Subjects who are current non-smokers, who have not used any tobacco products in the 12
month period preceding the screening visit, and have a pack history of years.

5. AST, ALT, alkaline phosphatase and bilirubin 1.5xULN
is acceptable if bilirubin is fractionated and direct bilirubin <35%).

6. No significant abnormality on 12-lead ECG at screening, including the following
specific requirements:

- QTcF < 450 msec

7. No clinically significant abnormality on the Holter ECG at screening.

8. FEV1 >/= 85% predicted at screening.

9. Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

10. Able to satisfactorily use the dry powder inhaler.

Exclusion Criteria:

1. As a result of medical interview, physical examination or screening investigations,
the principal investigator or delegate physician deems the subject unsuitable for the
study. Subjects must not have a systolic blood pressure above 145 mmHg or a diastolic
pressure above 85 mmHg unless the Investigator confirms that it is satisfactory for
their age.

2. The subject has any history of breathing problems in adult life (i.e. history of
asthmatic symptomatology).

3. Pregnant females as determined by positive serum hCG test at screening or by positive
serum/urine hCG test prior to dosing.

4. Lactating females.

5. The subject has been treated for or diagnosed with depression within six months of
screening or has a history of significant psychiatric illness.

6. Current or chronic history of liver disease, or known hepatic or biliary abnormalities
(with the exception of Gilbert's syndrome or asymptomatic gallstones).

7. Subjects who have suffered a lower respiratory tract infection within 4 weeks of the
screening visit.

8. History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.

9. Any adverse reaction including immediate or delayed hypersensitivity to any
beta-agonist, sympathomimetic drug, or any intranasal, inhaled or systemic
corticosteroid therapy. Known or suspected sensitivity to the constituents of the new
powder inhaler (ie lactose or magnesium stearate)

10. History of milk protein allergy.

11. Use of prescription or non-prescription drugs, including vitamins, herbal and dietary
supplements (including St John's Wort) within 7 days (or 14 days if the drug is a
potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first
dose of study medication, unless in the opinion of the Investigator and GSK Medical
Monitor the medication will not interfere with the study procedures or compromise
subject safety.

12. The subject has taken oral corticosteroids less than 8 weeks before the screening
visit.

13. The subject has taken inhaled, intranasal or topical steroids less than 4 weeks before
the screening visit.

14. History of alcohol/drug abuse or dependence within 12 months of the study. Abuse of
alcohol defined as an average weekly intake of greater than 21 units or an average
daily intake of greater than 3 units (males) or defined as an average weekly intake of
greater than 14 units or an average daily intake of greater than 2 units (females).

15. The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 3 months, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

16. Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.

17. Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within 3 months of the start of the trial.

18. A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening.

19. The subject has tested positive for HIV antibodies.

20. A positive pre-study urine drug screen or when randomly tested during the study.

21. Positive carbon monoxide (CO) or alcohol breath test at screening or on admission to
the Unit.

22. Consumption of seville oranges, pomelos (members of the grapefruit family) or
grapefruit juice from 7 days prior to the first dose of study medication.

23. Unwillingness or inability to follow the procedures outlined in the protocol.

24. Subject is mentally or legally incapacitated.