A Control Study to Evaluate The Efficacy And Safety of Ozone-therapy in Chronic Hepatitis B

• Status: Completed
• Trial end date: 2013-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the efficacy and safety of medical ozone in treatment of chronic hepatitis B patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nanfang Hospital of Southern Medical University
• Treatments: Interferons

Criteria

Inclusion Criteria:

• Male or female；

• HBsAg positive for over 6 months；

• ALT over 2×ULN, TBIL less than 80 µmol/L.

Exclusion Criteria:

• Patient has a history of hemorrhagic or hemolysis disease;

• Patient has any history of clinical signs/symptoms of hepatic decompensation or serious metabolic hepatic disease;

• Patient is co-infected with HIV or HCV;

• Patient is treated with anti-virus drug like interferon or nucleoside analogue in recent 6 months;

• Patient is treated with immunosuppressive agent for long time, including patient has a history of organ transplantation;

• Pregnancy;

• Current alcohol or drug abuse;

• Difficulty to draw blood through veins;

• Patient has a history of carcinoma, or finding suggestive of possible hepatocellular carcinoma (HCC), or AFP over than 100ng/ml;

• Patient has a history of any severe physical disease such as cardio-vascular, kidney events, hyperthyroidism or serious electrolyte disturbance;

• Patient is enrolled in any other clinical trials.