Overview

A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine

Status:
Completed
Trial end date:
2008-04-01
Target enrollment:
0
Participant gender:
All
Summary
Characterize the relative abuse liability of a short versus a long acting opioid in chronic pain patients.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of California, Davis
Treatments:
Acetaminophen
Amphetamine
Hydrocodone
Morphine
Phenobarbital
Criteria
Inclusion Criteria:

- Patients with chronic pain for periods greater than 6 months

- Patients taking greater than 80 mg morphine equivalents of a short acting opioid (>8
vicodin or 4 oxycodone/day)

- Referral to Pain or Substance Abuse Clinic for self-escalation of opioids

Exclusion Criteria:

- Inability to understand and comprehend spoken English

- Patients with Munchausen's syndrome

- Patient has a history of Peripheral Vascular Disease

- Patient has a history of Raynaud's Phenomenon

- Liver Disease; Child's classification greater than 1 (liver cirrhosis) will be
excluded

- Renal disease (BUN >25 or Cr >1.5)

- Congestive Heart Failure; Subjects with New York Heart Association (NYHA)Heart Failure
Symptom Classification System Level of Impairment II, III and IV will be excluded

- Coronary artery disease; recent MI within the past six months or recent history of
angina not controlled with NTG within the past six months

- Hypertension; 1)previously normotensive subject; systolic bp >140 mm Hg and diastolic
bp > 90 mm Hg 2) Hx of active treatment with antihypertensive medications; systolic bp
>150 mm Hg and diastolic bp > 100 mm Hg

- Cerebrovascular disease; recent history within the past year of a transient ischemic
attack or recent history within the past year of a cerebrovascular event

- Malignancy requiring active treatment

- Patient is pregnant (as ascertained by a self-report and a mandatory commercial
pregnancy test before any study medication is consumed)