A Comparison of Three Nebulizers for Standard Clinical and Research Use in Methacholine Challenge Testing

• Status: Completed
• Trial end date: 0000-00-00
• Target enrollment: 60
• Participant gender: Both

Summary

The study will assess three different nebulizers for use in methacholine challenge testing in order to determine if the Aeroneb Solo would make a suitable replacement for the long-used and now obsolete Wright and Bennett-Twin nebulizers. Results from each device will be compared to evaluate whether current guidelines for the methacholine challenge should be updated for superior standardization.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Treatments: Methacholine Chloride
• Last Updated: 2016-10-13

Criteria

Inclusion Criteria:

• Men and women aged 18 or older

• Stable asthma

• Baseline methacholine PC20 less than or equal to 16mg/mL

• Baseline lung function greater than 65% predicted

Exclusion Criteria:

• Use of long-acting bronchodilators within 30 days of Visit 1

• Pregnant or nursing

• Cardiovascular problems

• Respiratory illness within 4 weeks of Visit 1

• Allergen-induced asthma exacerbation within 4 weeks of Visit 1