A Comparison of Sedative Drugs for Conscious Sedation During Ultrasound Guided Transbronchial Needle Aspiration
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
1. Appropriate sedation is needed for medical diagnosis, treatment, and the safety for
patients. In non-surgical approaches, benzodiazepines are broadly used for ideal sedated
status for patients.
- However, especially in bronchoscope procedure, continuous monitoring of oxygen
saturation is needed to prevent hypoxia due to respiratory distress induced by
benzodiazepine.
- A alpha-2 agonist, dexmedetomidine, which has similar sedative effect, but has less
adverse effect of respiratory distress compared to previous agents, was introduced.
2. It is necessary to compare the efficacy and safety of dexmedetomidine with that of
midazolam in ultrasound guided transbronchial needle aspiration (EBUS-TBNA).
- Double blind randomized trial
- Primary outcome: The number and duration of desaturation, volume of sedative, any
use of rescue midazolam, and Ramsay Sedation Scale (RSS) score (for efficacy), and
hypertension, tachycardia, any need for mandible support or manual ventilation, and
any need for intubation (for safety).