A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation

• Status: Completed
• Trial end date: 2017-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Renal ischemia/reperfusion (I/R)-induced injury is known to be associated with immediate and long-term hepatic dysfunction after liver transplantation. Protecting the liver against I/R injury and maintaining hepatic function during transplant surgery is therefore very important in order to improve post-operative outcome. This purpose of this study is to investigate whether propofol anesthesia done in both liver donors and recipients during living-donor liver transplantation is effective in reducing liver I/R injury via its antioxidant and antiinflammatory properties and improve post-transplant outcome compared to desflurane anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Anesthetics; Desflurane; Isoflurane; Propofol

Criteria

Inclusion Criteria:

(1) Adult liver donors and recipients scheduled for liver transplantation

Exclusion Criteria:

1. Patient refusal

2. Hypersensitivity to propofol, soybeans or peanuts

3. History of vitamin C or E intake within 5 days before surgery

4. History of acute myocardial infarct within 6 months before surgery

5. Congestive heart failure (NYHA III-IV)

6. Autoimmune disease patients

7. BMI over 30 kg/m2

8. Left ventricular ejection fraction less than 35% upon preoperative echocardiography