A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy of pregabalin to placebo for postoperative pain control after photorefractive keratectomy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: 59th Medical Wing; Wilford Hall Medical Center
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

• Healthy ocular status

• Stable preoperative refractive anisometropia

• Consented to the PRK surgical procedure

Exclusion Criteria:

• Pregnant or breastfeeding

• Diagnosed with autoimmune disease or diabetes

• Patients with a known adverse reaction or hypersensitivity to gabapentin or pregabalin

• Patients only desiring PRK on one eye

• Patients with history of drug use/abuse/addiction

• Patients who are on chronic pain medications

• Patients currently taking anti-epileptic, antidepressant and/or anti-psychotic medications

• Patients with a history of suicidality

• Patients with chronic renal insufficiency (defined as estimated creatinine clearance less than 30ml/min or Scr ≥ 2.0) 10) Patients who have experienced angioedema, or have heart failure