A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain.

• Status: Completed
• Trial end date: 2021-02-02
• Target enrollment: 0
• Participant gender: All

Summary

Purpose: This is a randomized clinical trial comparing the effects of three different medications for acute low back pain (LBP):Ketorolac, Ibuprofen, Diclofenac

Hypothesis: A daily regimen of ketorolac will provide greater relief of LBP than ibuprofen or diclofenac 5 days after an emergency department (ED) visit, as measured by the Roland Morris Disability Questionnaire (RMQ)

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Montefiore Medical Center
• Treatments: Diclofenac; Ibuprofen; Ketorolac; Ketorolac Tromethamine

Criteria

Inclusion Criteria:

• Men or women age 18-64.

• Present to ED primary for management of Low Back Pain (LBP)

• Functionally impairing back pain: A baseline score of greater than 5 on the Roland-Morris Disability Questionnaire

• Musculoskeletal etiology of low back.

• Non-radicular pain.

• Pain duration <2 weeks (336 hours).

• Non-traumatic LBP

• Participant is to be discharged home.

Exclusion Criteria:

• Flank pain, that is pain originating from tissues lateral to the paraspinal muscles.

• Not available for follow-up

• Pregnant

• Chronic pain syndrome

• Allergic to or intolerant of investigational medications

• Contra-indications to investigational medications