A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adults
Status:
Withdrawn
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the effectiveness of two different augmentation
strategies of antidepressant treatment for depressed older adults who have not responded to
an adequate trial of antidepressant medication. The first augmentation strategy is Problem
Solving Therapy (PST), a 12-week psychotherapy treatment that has been shown to be effective
in depressed older adults. The second augmentation strategy is medication augmentation, which
will begin with six weeks of aripiprazole, an atypical antipsychotic medication that has also
been shown to be effective in depressed older adults who have failed a trial of
antidepressant medication.