A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
This is a pilot study to compare the hemodynamic changes that occur during induction with a
novel drug combination known as ketofol (propofol and ketamine admixture with that of
propofol alone (prototypic anesthesia induction agent). Propofol and ketamine are widely used
as induction agents and their effects on patient hemodynamics are well known. Some of these
drug-induced hemodynamic changes are undesirable and lead to deleterious effects on patient
hemodynamics. We seek to investigate the hemodynamic changes associated with a novel drug
combination known as ketofol (ketamine/propofol admixture) during induction and compare them
to propofol. If we determine that the changes produced by ketofol are favorable compared with
propofol, we then will seek to test its use in the trauma setting in a subsequent randomized
controlled trial.