A Comparison of Four Different Treatment Regimens of Helicobacter Pylori in Chinese Children
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
With the resistance of Helicobacter pylori increasing, low and unsatisfactory eradication
rate (64%) have been observed with standard triple therapy in European children. Which
regimen is appropriate for Chinese children? There is no large scale, multi center studies in
China about treatment, CYP2C19 gene polymorphism, resistance rate and resistance genotype.
Investigators want to perform a research to compare four different treatment regimens（triple
therapy, sequential therapy, bismuth quadruple therapy and concomitant therapy）as the
first-line treatment of Helicobacter pylori in Chinese children and investigation of
resistance, impact factors and changes of microbiota after the therapy. The results of the
study will provide theoretical basis to make the new guideline of diagnosis and therapy of
Helicobacter pylori in Chinese children. It advance instruct and norm the clinical practice
for Chinese pediatrician to increase the cure rate of Helicobacter pylori and decrease the
resistance.
Phase:
N/A
Details
Lead Sponsor:
Ying HUANG
Collaborators:
Beijing Children's Hospital Guangzhou Women and Children's Medical Center Tang-Du Hospital The Children's Hospital of Zhejiang University School of Medicine