Overview

A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
Evaluate the effectiveness rate of dapsone plus trimethoprim as a therapy for the first episode of Pneumocystis carinii pneumonia (PCP) in AIDS patients. Compare the rates and severity of adverse effects using dapsone versus trimethoprim - sulfamethoxazole (TMP / PurposeX). Establish relative toxicities with regard to suitability for outpatient treatment.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Jacobus Pharmaceutical
Treatments:
Dapsone
Sulfamethoxazole
Trimethoprim
Trimethoprim, Sulfamethoxazole Drug Combination
Criteria
Exclusion Criteria

Concurrent Medication:

Excluded:

- Requirement for other medications found to be effective in the treatment of
Pneumocystis carinii pneumonia (PCP) (i.e., DFMO, pyrimethamine, and sulfadiazine).

Patients with the following are excluded:

- History of allergic reaction to dapsone.

- Requirement for other medications found to be effective in the treatment of
Pneumocystis carinii pneumonia (PCP) (i.e., DFMO, pyrimethamine, and sulfadiazine).

- Patients subsequently found to be glucose-6-phosphate dehydrogenase (G6PD) positive
will be withdrawn from the study and treated with another regimen.

Prior Medication:

Excluded:

- Requirement for other medications found to be effective in the treatment of
Pneumocystis carinii pneumonia (PCP) (i.e., DFMO, pyrimethamine, and sulfadiazine).

Patients who are glucose-6-phosphate dehydrogenase (G6PD) positive will be withdrawn from
the study and treated with another regimen.

Hospitalized patients with first episode of Pneumocystis carinii pneumonia (PCP) documented
by GIEMSA or methenamine stain.

- Patients must:

- Be willing and able to give informed consent.

- Be expected to survive 1 week without therapy.

- Have less than 48 hours of treatment for Pneumocystis carinii pneumonia (PCP) for this
episode.