A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

• Status: Completed
• Trial end date: 2006-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare radiofrequency catheter ablation and antiarrhythmic drug treatment for the maintenance of sinus rhythm in paroxysmal atrial fibrillation patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Biosense Webster, Inc.
• Treatments: Amiodarone; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cifenline; Dofetilide; Flecainide; Propafenone; Quinidine; Sotalol

Criteria

Inclusion Criteria:

• 18 years of age or older

• Paroxysmal atrial fibrillation for at least 6 months with at least 2 symptomatic episodes (patient history) during the previous month

• Atrial fibrillation (patient history or echocardiogram documented) resistant to at least one antiarrhythmic drug of Class I or III

• Documentation of at least one episode of atrial fibrillation on 12-lead echocardiogram or Holter Monitor

Exclusion Criteria:

• Contraindications to more than 2 antiarrhythmic drugs of different classes, or to oral anticoagulants

• History of any previous ablation for atrial fibrillation

• Intracardiac thrombus

• Atrial fibrillation due to reversible cause

• Pregnancy

• Contraindication to stopping oral anticoagulation (for example as a result of a mechanical cardiac valve)