A Comparison Study of Oxybutynin and Botulinum Toxin for Neurogenic Detrusor Overactivity

• Status: Completed
• Trial end date: 2010-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the effects of oral oxybutynin and intradetrusor injections of botulinum toxin type A on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity following spinal cord injury.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centro de Reabilitação e Readaptação Dr. Henrique Santillo
• Treatments: abobotulinumtoxinA; Botulinum Toxins; Botulinum Toxins, Type A; incobotulinumtoxinA; Mandelic Acids; onabotulinumtoxinA; Oxybutynin

Criteria

Inclusion Criteria:

• Spinal cord injury

• Detrusor overactivity

• Age over 18 years

• Spinal cord injury at least 12 months duration

• Undergoing regular clean intermittent catheterisation

Exclusion Criteria:

• Pregnancy

• Desire to become pregnant during the study period

• Breastfeeding

• Blood coagulation disorder

• Neuromuscular transmission disorder

• Use of any intravesical pharmacologic agents

• Previous use of botulinum toxin A