A Comparative Study of Combination Antiretroviral Therapy in Children and Adolescents With Advanced HIV Disease
Status:
Completed
Trial end date:
1998-11-01
Target enrollment:
Participant gender:
Summary
To compare the antiviral activity, safety, toxicity, and steady-state pharmacokinetics of
zidovudine, didanosine, and nevirapine used in combination in patients with HIV infection.
The duration of clinical benefit from zidovudine (AZT) may be limited because of development
of viral resistance to the drug. Use of combination antiretroviral therapy can potentially
reduce viral load and prevent emergence of multidrug resistance.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)