Overview A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL) Status: Active, not recruiting Trial end date: 2022-07-31 Target enrollment: Participant gender: Summary Previously untreated CD20 positive diffuse large B-cell lymphoma (DLBCL) requiring full course chemoimmunotherapy. Phase: Phase 1/Phase 2 Details Lead Sponsor: University Hospital Southampton NHS Foundation TrustTreatments: AcalabrutinibCyclophosphamideDoxorubicinPrednisoloneVincristine