Overview

A Clinical Trial to Demonstrate the Efficacy of Cangrelor

Status:
Terminated
Trial end date:
2010-06-01
Target enrollment:
0
Participant gender:
All
Summary
The primary objective of this study is to demonstrate that the efficacy of cangrelor is superior, or at least non-inferior, to that of clopidogrel in subjects requiring PCI.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
The Medicines Company
Treatments:
Cangrelor
Clopidogrel
Ticlopidine
Criteria
INCLUSION CRITERIA

To be included in this study, subjects must meet the following criteria:

- Angiography demonstrating atherosclerosis amenable to treatment by percutaneous
coronary intervention (PCI) with or without stent implantation and diagnosis of Acute
Coronary Syndrome (ACS) by elevated cardiac markers or ischemic chest discomfort
w/electrocardiogram changes + age > 65 or diabetes or ST-elevation MI.

EXCLUSION CRITERIA

Subjects will be excluded from the study if they present with any of the following:

1. Not a candidate for PCI

2. Increased bleeding risk: ischemic stroke within the last year or any previous
hemorrhagic stroke, tumor, cerebral arteriovenous malformation, or intracranial
aneurysm; recent (<1 month) trauma or major surgery (including by-pass surgery);
currently receiving warfarin, active bleeding

3. Impaired hemostasis: known International Normalized Ratio (INR) >1.5 at screening;
past or present bleeding disorder (including congenital bleeding disorders such as von
Willebrand's disease or hemophilia, acquired bleeding disorders, and unexplained
clinically significant bleeding disorders), thrombocytopenia (platelet count
<100,000/µL), or history of thrombocytopenia or neutropenia associated with
clopidogrel

4. Severe hypertension not adequately controlled by antihypertensive therapy at the time
of randomization

5. Receipt of fibrinolytic therapy in the 12 hours preceding randomization

6. Receipt of clopidogrel dose exceeding maintenance dose (ie, >75 mg) at any time in the
5 days preceding randomization

7. Inability to swallow study capsules

8. Glycoprotein IIb/IIIa (GPI) Inhibitor usage within the previous 12 hours [applicable
to unstable angina (UA) and non-ST-elevation myocardial infarction (NSTEMI) patients]

Subjects excluded for any of the above reasons may be re-screened for participation at any
time if the exclusion characteristic has changed.