Overview

A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy

Status:
Unknown status

Trial end date:
2016-12-01

Target enrollment:

Participant gender:

Summary

At present, the most effective drugs to osteosarcoma include ADM,DDP,,HD-MTX,IFO and so on.The effective rate of single drug was about 30%, and if the chemotherapy contains HD-MTX, the survival rate can reach about 60%, so the HD-MTX is the most important component in patients of osteosarcoma. Studies have shown that, MTX efficacy and adverse reactions were associated with blood concentration level and duration, selecting the right time and dose to give CF is the critical point.

Phase:

N/A

Details

Lead Sponsor:

Tianjin Medical University Cancer Institute and Hospital

Treatments:

Calcium
Calcium, Dietary
Leucovorin
Levoleucovorin
Methotrexate