71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify
for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has
been suggested in previous studies.
Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors,
the investigators hypothesis is that women with PCOS and with the variant allele G have a
poor response on hirsutism and on hormonal and metabolic variables after oral contraceptive
pill (OCP) treatment for 6 months.
Phase:
N/A
Details
Lead Sponsor:
Federal University of Rio Grande do Sul
Collaborators:
Conselho Nacional de Desenvolvimento Científico e Tecnológico Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Hospital de Clinicas de Porto Alegre