7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumonia
Status:
Active, not recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
There is evidence that using shorter antibiotic regimens may help in decreasing antimicrobial
resistance and reducing drug-related adverse events.6 Moreover, short-course treatments were
found to be as effective as longer-course antibiotic treatment.7,8 In a pooled analysis of
four randomized trials in VAP comparing shorter versus long duration of antibiotics in the
management of VAP, no difference in the mortality was found. We hypothesize that the use of
short course of antibiotics in the treatment of VAP due to drug resistant Acinetobacter
baumanii (sensitive to carbapenems and/or colistin only) may result in a higher
antibiotic-free days and drug related adverse events, in comparison to a longer duration of
antibiotics. In this study, we propose to study a 7-day versus 14-day course of antibiotics
in patients with drug-resistant Acinetobacter baumanii.
Phase:
N/A
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research