68Ga-pentixather and 68Ga-pentixafor PET/CT in Multiple Myeloma
Status:
Recruiting
Trial end date:
2024-08-01
Target enrollment:
Participant gender:
Summary
Chemokine receptor-4 (CXCR4) is overexpressed in multiple myeloma (MM) cells. 68Ga-pentixafor
is a radio-labled tracer for CXCR4 . 68Ga-pentixafor PET/CT has shown good diagnostic
performance in MM. But an exchange of Ga3+ by Lu3+ or Y3+ will lead to a significant loss of
CXCR4 affinity. Investigators conduct this prospective study to evaluate the diagnostic
performance of 68Ga-pentixather compared with 68Ga-pentixafor, in order to parallel
68Ga-pentixather and 177Lu/90Y-pentixather in theranostics of MM.