The Nectin-4 protein belongs to the cell adhesion factors family and has a tissue-specific
expression spectrum in normal human tissues. However, Nectin-4 is overexpressed in various
malignancies, especially those of epithelial origins, such as uroepithelial carcinoma, making
Nectin-4 a highly specific and significant imaging target for malignancies.
[68Ga]N188, a novel molecular probe of PET imaging agent that targets Nectin-4, can be used
in the diagnosis and research of a wide variety of Nectin-4 high-expression malignancies,
including bladder cancer.