68Ga-BMV101 PET/CT in Patients With Idiopathic Pulmonary Fibrosis
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Inflammation mediated by macrophage infiltration plays a vital role in a diverse range of
physiological conditions. In particular, recent evidence suggests this type of macrophage
response is important for the disease pathology of pulmonary fibrosis. Because cysteine
cathepsins are proteases that are highly expressed in antigen presenting cells such as
macrophages, they serve as promising biomarkers. Employing non-invasive imaging agents
68Ga-BMV101 that specifically recognize cysteine proteases in immune cells has the potential
to not only aid early detection but also significantly aid efforts to monitor progression and
patient response to therapy.