5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Opioid medications are commonly used for pain relief. When given over time, physical
dependence can occur. This results in unpleasant side effects (such as agitation and nausea)
if opioid medications are suddenly stopped. This study aims to test the use of the drug
ondansetron to reduce the symptoms associated with opioid withdrawal and to prevent the
progression of opioid physical dependence, thereby allowing future investigators to better
test the role of physical dependence in the development of addiction and also possibly
improving acceptance of abstinence-based programs for addiction.