5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females
Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
The investigators hypothesize that the administration of two widely available, naturally
occurring dietary supplements, 5 hydroxytryptophan and creatine monohydrate, will reduce the
severity of depression in individuals exposed to chronic hypoxia by living at altitude. The
purpose of this study is to determine if 8 weeks of dietary augmentation with oral 5 g
creatine daily and 100 mg 5-HTP twice daily reduces hypoxia-related depressive symptoms
measured by the 17-item Hamilton Depression Rating Scale (HAM-D) in women with SSRI or
SNRI-resistant depression.