5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

A five day quadruple concomitant therapy is as effective and safe as a 10 day sequential therapy for eradication of H. pylori infection.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second University of Naples; University of Campania "Luigi Vanvitelli"
• Treatments: Amoxicillin; Esomeprazole; Levofloxacin; Ofloxacin; Proton Pump Inhibitors; Tinidazole

Criteria

Inclusion Criteria:

• H. pylori-infected patients who were at least 18 years of age and who had never received H. pylori eradication treatment were included in the study.

Exclusion Criteria:

• previous treatment for H. pylori infection,

• use of inhibitors of acid secretion and/or antibiotics during the 6 weeks before the study,

• gastrointestinal malignancy,

• previous gastro-oesophageal surgery,

• severe concomitant cardiovascular,

• respiratory or endocrine diseases,

• clinically significant renal or hepatic disease,

• hematologic disorders,

• any other clinically significant medical condition that could increase risk,

• history of allergy to any of the drug used in the study,

• pregnancy or lactation,

• alcohol abuse,

• drug addiction,

• severe neurologic or psychiatric disorders, and

• long-term use of corticosteroids or anti-inflammatory drugs.