Overview

4-methylpyrazole and Acetaminophen Metabolism

Status:
Completed
Trial end date:
2018-10-31
Target enrollment:
0
Participant gender:
All
Summary
Oxidative metabolism of APAP will be studied with and without 4-MP.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Arizona
Treatments:
Acetaminophen
Fomepizole
Criteria
Inclusion Criteria:

- Healthy

- No APAP use in previous 2 weeks

- No ingestion of alcohol or drugs that affect CYP 2E1 over previous 5 days

- No allergy to APAP or fomepizole

- BMI < 29

Exclusion Criteria:

- Pregnant or lactating

- History of alcohol abuse

- Allergy to APAP or fomepizole

- Screening LFTs above normal range