Overview

3D PET Myocardial Blood Flow and Rb82 Infusion Profiles

Status:
Recruiting
Trial end date:
2022-06-30
Target enrollment:
0
Participant gender:
All
Summary
The investigators seek to test bolus infusions (50ml/min) vs. slow infusions (20 ml/min) of Rb-82 on metrics of coronary blood flow assessed on a modern 3D PET/CT.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Ochsner Health System
Collaborator:
Bracco Corporate
Criteria
Inclusion Criteria:

Normal Volunteers

- Adults ≥18 and <40 years old able to give informed consent.

- Ability to abstain from caffeine for 48 hours

The "clinical" population

- Adults ≥18 years old able to give informed consent.

- Any cardiac risk factor including hypertension, hyperlipidemia, diabetes mellitus or
tobacco use OR

- CAD defined by with history of PCI or CABG, Coronary Ca score>400, or dense coronary
calcifications noted on chest CT

- Ability to abstain from caffeine for 48 hours

The "infarct" population

- Adults ≥18 years old able to give informed consent.

- Prior cardiac PET scan demonstrating a fixed defect ≥ 15% of the LV myocardium with
relative uptake ≤60% maximum uptake.

- In addition, to the perfusion defect, each volunteer requires either:

- FDG PET or MRI viability studies confirming infarct OR

- akinesis and wall thinning on ECHO within the same territory as the PET defect in
addition to Q-waves on ECG

- Ability to abstain from caffeine for 48 hours

Exclusion Criteria:

Normal Volunteers

- Any chronic cardiac disease or condition (e.g., hypertension, hyperlipidemia)

- Any chronic systemic disease or condition (e.g., diabetes, systemic lupus, rheumatoid
arthritis)

- Tobacco use

- Family history in a first degree relative with clinical CAD (h/o PCI, MI or CABG) in
men <55 or women <65

- Severe claustrophobia

- Positive urine pregnancy test

- Inability to give informed consent

- BMI ≥ 30 or BMI>25 and <30 provided waist to hip ratio >0.80 in women or 0.90 in men.

The "clinical" and "infarct" populations

- Severe claustrophobia

- Hemodynamic instability or unstable symptoms

- Positive urine pregnancy test

- Inability to give informed consent