2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies
Status:
Recruiting
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
This phase II trial studies how well a 2-step approach to stem cell transplant works in
treating participants with blood cancers. Giving chemotherapy and total body irradiation
before a lymphocyte (white blood cell) and stem cell transplant helps stop the growth of
cells in the bone marrow including normal blood-forming cells (stem cells) and cancer cells.
By giving the donor cells in two steps, the dose of lymphocytes given can be tightly
controlled and they can be made more tolerant to the body. When the healthy lymphocytes and
stem cells from a donor are infused into the participant, they may help the participant's
bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the
transplanted cells from a donor can make an immune response against the body's normal cells
called graft versus host disease. Giving tacrolimus and mycophenolate mofetil may stop this
from happening.
Phase:
Phase 2
Details
Lead Sponsor:
Sidney Kimmel Cancer Center at Thomas Jefferson University