Overview

1H Magnetic Resonance Spectroscopy in Migraine Patients

Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
0
Participant gender:
Female
Summary
To investigate the glutaminergic system in the onset of migraine-like attacks.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Leiden University Medical Center
Collaborators:
European Commission
Netherlands Organisation for Scientific Research
Treatments:
Nitroglycerin
Criteria
Inclusion Criteria:

- Diagnosed with migraine without aura according to the International Classification of
Headache Disorders (ICHD)-3 beta criteria from 2013.

- At least one migraine attack per month in the preceding six months

Exclusion Criteria:

- Other neurological disorders apart from migraine

- Chronic medication apart from oral contraceptives

- Migraine with aura

- Chronic migraine with 15 or more headache days per month/with 8 or more migraine days
per month

- Medication-overuse headache (ICHD-3 beta criteria)

- Women who are breastfeeding, pregnant, or planning to become pregnant

- Contra-indications for 7 tesla MRI scanner

- Contra-indications for GTN administration (e.g. nitrate allergy, heart condition)

- Healthy controls (with no first degree relative with migraine or trigeminal autonomic
cephalalgia)