18F ML-10 for Early Detection of Response of Brain Metastases to SRS
Status:
Terminated
Trial end date:
2009-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the potential of [18F]-ML-10 to serve as a
non-invasive imaging tool for the early detection of apoptosis in brain metastases in
response to radiation therapy, in patients subjected to stereotactic radiosurgery (SRS). Such
early detection may improve clinical management of patients with brain metastases, as it may
help early identification of non-responders, and subsequently potentially lead to
optimization of radiation techniques such as the need for whole brain radiation therapy
(WBRT), addition of brain penetrating chemotherapy or an early decision on referral of the
patient with non-responsive lesions to surgery or to systemic chemotherapy. The experimental
design of the present study aims to evaluate the potential of non-invasive PET examination
with [18F]-ML-10, to provide the clinician with an assessment of response early in the course
of treatment, via non-invasive molecular imaging of radiation-induced apoptosis. This
information on tumor responsiveness is currently available only several weeks to months after
completion of radiotherapy.