18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia

• Status: Available
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This purpose of this study is to determine the ability of an 18F-fluoro-L-dihydroxyphenylalanine (18F-DOPA) PET scan to detect a focal lesion of hyperinsulinism and determine the location in patients with congenital hyperinsulinism, Beckwith Wiedemann Syndrome and suspected insulinoma. Safety data will be collected.

Details

• Lead Sponsor: Children's Hospital of Philadelphia

Criteria

Inclusion Criteria:

• Subjects of any age with hyperinsulinemic hypoglycemia, diagnosed by a fasting test and/or response to glucagon stimulation.

• Subjects who are eligible for pancreatic surgery regardless of prior pancreatic surgery

Exclusion Criteria:

• Pregnant or lactating females

• Any other major illness or condition that in the investigator's judgment will substantially increase the risk associated with the subject's participation in this study

• Subjects who are not a candidate for pancreatic surgery