15-day Sequential Therapy for Helicobacter Pylori Infection in Korea
Status:
Completed
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
10-day sequential therapy was not sufficient to overcome tough situation for H. pylori
eradication in Korea due to high antimicrobial resistance. The present investigators assumed
that doubling duration of second phase of sequential therapy might have more potent
bactericidal efficacy than previous 10-day sequential regimen. But 15-day regimen with
initial 5-day PPI with amoxicillin followed by remaining 10-day PPI, clarithromycin with
metronidazole was not ever tested before. Moreover, whether extending the sequential therapy
to 15-day might be more effective than 10-day sequential therapy is unknown especially in
Korea. From this background, the present investigators prepared clinical trials regarding
modified sequential therapy which was extending the treatment duration to 15 days compared
than previous 10-day sequential therapy regimen. In addition, pre-treatment antimicrobial
susceptibility testing was performed to find the possibility to overcome antimicrobial
resistance.
Phase:
Phase 4
Details
Lead Sponsor:
Seoul National University Bundang Hospital
Collaborator:
Ministry of Education, Republic of Korea (2012R1A1A3A04002680)