11C-PIB PET Study in MESA at Columbia University

• Status: Enrolling by invitation
• Trial end date: 2023-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will conduct a study of brain positron emission tomography (PET) using 11C-PIB for the imaging of brain amyloid in 250 participants in the Multiethnic study of atherosclerosis (MESA) at Columbia University Irving Medical Center in New York City. Participants will be imaged only once with Pittsburgh Compound B (PIB) PET.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: José A. Luchsinger
• Collaborators: National Institute on Aging (NIA); Wake Forest University

Criteria

Inclusion Criteria:

• Current participants in MESA study at Columbia University

• 60 years or older

• Fluent in English and/or Spanish.

• Able to participate in all scheduled evaluations and to complete all required tests and procedures.

Exclusion Criteria:

• Active treatment for cancer

• Any serious medical condition which would prevent long-term participation

• Pregnancy

• Weight >300 pounds

• Participants previously diagnosed or adjudicated to have dementia

• Participants unwilling to undergo cognitive testing

• Plans to leave the community within five years

• Language barrier (speaks other than English, Spanish, Chinese)

• Inability to give informed consent or to obtain consent from a Legally Authorized Representative (LAR)