0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka

• Status: Terminated
• Trial end date: 2018-06-27
• Target enrollment: 0
• Participant gender: All

Summary

Total knee and hip replacements are some of the most common orthopedic procedures that require aggressive postoperative pain management. This management helps us to improve clinical outcomes such as participation in early physical therapy, hospital discharge, and patient satisfaction. Based on the recent anatomical evidence and the investigator's knowledge of the complexity of the knee joint innervation the investigator proposes a new regional anesthesia technique that provides a complete sensory blockade and better analgesia while preserving the quadriceps strength and avoiding the potential for foot drop caused by inadvertent blockade of the common peroneal nerve.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Montefiore Medical Center
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• All patients undergoing unilateral total knee replacement due to OA or rheumatoid arthritis

• Ages 40- 80 years old

• American Society of Anesthesiologists class I-III

Exclusion Criteria:

• Refusal or absolute medical contraindication to peripheral nerve block

• refusal or absolute medical contraindication to spinal anesthesia

• conversion of spinal anesthesia to general anesthesia is obtained

• inability to cooperate

• allergy to any drug used in this study

• daily intake of opioids (tramadol, morphine, oxycodone, methadone, fentanyl)

• alcohol dependence or use of any illegal drugs within the last month

• inability to perform the mobilization test and timed up and go (TUG) test pre-operatively