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Clinical Trials for Nervous System Diseases

• Safety and Tolerability of Glyceryl Tribenzoate (GTB) Capsules in Healthy Subjects
• Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke
• Non-inferiority Study of Rituximab Compared to Ocrelizumab in Relapsing MS
• A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)
• Absorption, Metabolism, Excretion and Absolute Bioavailability of EDG-5506 in Healthy Volunteers
• Psilocybin in Functional Neurological Disorder
• Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome
• Gadopiclenol Pharmacokinetics, Safety and Efficacy in Children < 2 Years of Age
• Role of Parasympathetic Activity in Mild to Moderate Asthma With Irreversible or Fixed Airflow Obstruction
• A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese Population
• An Open-Label Extension of XPro1595 in Patients With Alzheimer's Disease
• Proximal Lower Limb Intramuscular Block : Effects on Hemiparetic Gait
• A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
• Extension of AOC 1001-CS1 (MARINA) Study in Adult Myotonic Dystrophy Type 1 (DM1) Patients
• Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/Her2- Breast Cancer
• Propranolol on Post Stroke Immune Status and Infection
• Evaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbances
• Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of Inflammation
• Study to Assess the Efficacy of XPro™ in Patients With Mild Alzheimer's Disease With Biomarkers of Inflammation
• A Study to Investigate the Safety and Efficacy of Ricolinostat
• Evaluate the Safety and Pharmacokinetics of Ricolinostat
• Efficacy of Diterpene Ginkgolides Meglumine Injection in Elderly Patients With Ischemic Stroke
• A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy (HOPE-3)
• For Patients With Ischemic Stroke, Clinically Study the Effectiveness and Safety of Butylphthalide.
• Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
• Phase 1 ALKS 1140 in Healthy Adults
• Flupentixol and Melitracen Tablets in the Treatment of Emotional Disorder
• Dopaminergic Therapy for Frontotemporal Dementia Patients
• An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE
• Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia
• Adjunctive Use of Fute (Flupentixol) in Multi-acting Receptor-targeted Antipsychotics Treated Schizophrenia Patients
• Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease
• NAD Supplementation to Prevent Progressive Neurological Disease in Ataxia Telangiectasia
• A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)
• XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy
• Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Idiopathic Inflammatory Diseases of the Nervous System
• Impact Dexmedetomidine on Postoperative Delirium in Patients After Intracranial Operation for Brain Tumor
• Role of Sympathetic Activation in Ischemia Reperfusion Injury
• Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
• Dexmedetomidine for Prevention of Postoperative Delirium After Intracranial Operation for Brain Tumor
• Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
• The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients
• 1H Magnetic Resonance Spectroscopy in Migraine Patients
• Effects of Cold Application and Heparinoid on Periorbital Edema and Ecchymosis
• Dextrose, Corticosteroids and Surgical Release in Carpal Tunnel Syndrome
• Combined Intrathecal and Intravenous VTS-270 Therapy for Liver and Neurological Disease Associated With Niemann-Pick Disease, Type C1
• Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy
• Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease. Extension to HP-CD-CL-2002 Clinical Study
• CKD-355 Drug-drug Interaction Study (CKD-355 DDI P1)
• Safety and Efficacy of Melatonin in Patients With Multiple Progressive Primary Sclerosis
• Is Sphenopalatine Ganglion Block Treatment Effective on Postspinal Headaches
• Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury
• Fluoxetine Opens Window to Improve Motor Recovery After Stroke
• Study of Pioglitazone in Sporadic Inclusion Body Myositis
• The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes
• A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy
• Open-label Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Children With Status Epilepticus (Convulsive) in a Healthcare Setting in Japan
• Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Pediatric Patients With Status Epilepticus (Convulsive) in the Community Setting
• Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease
• Trial to Assess the Pharmacokinetics, Safety, Tolerability of Oral Brexpiprazole in Children (6 to <13 Years Old) With Central Nervous System Disorders
• The Preventive Treatment of Migraine With Low-Dose Naltrexone and Acetaminophen Combination
• Long-Term Outcomes of Ataluren in Duchenne Muscular Dystrophy
• AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)
• Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST)
• Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease
• Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension
• Repeat of: A Study to Evaluate Efficacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With Fibromyalgia
• EDS in Ataxia Telangiectasia Patients
• PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome
• Autoimmune Basis for Postural Tachycardia Syndrome
• First-in-man Study of Single Ascending Dose of a New Drug for Neurological Disorders
• First-in-man Study of Single and Multiple Ascending Doses of a New Drug for Neurological Disorders
• Comparison of the Analgesic Effect of Different Local Anesthetics in Interscalene Nerve Block for Shoulder Surgery
• General Anesthesia for Endovascular Thrombectomy; A Pilot Study.
• Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure
• Gastrointestinal Motility Among Diabetes Patients
• EXTEND EXpanding Treatment for Existing Neurological Disease
• A Efficacy and Safety Study of Intramuscular Injection of Human Placenta-Derived Cells (PDA-002) in Subjects With Diabetic Peripheral Neuropathy
• Intrathecal Rituximab in Progressive Multiple Sclerosis
• Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection
• A Study to Evaluate eFFIcacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With fibRoMyalgia
• Botulinum Toxin-A for Sialorrhoea Treatment in Asian Adults With Neurological Diseases
• Clinical Translation of 18F-Labeled Hydroxyphenethylguanidines
• Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study)
• Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion
• Retrospective Study of MRI in Pediatric Patients
• Topical Vancomycin for Neurosurgery Wound Prophylaxis
• Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability
• Testosterone Plus Finasteride Treatment After Spinal Cord Injury
• An Extension Study of Ataluren (PTC124) in Participants With Nonsense Mutation Dystrophinopathy
• The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy
• Establishment of Clinical Basis for Hematopoietic Growth Factors Therapy in Brain Injury
• Adherence to Treatment, Safety and Tolerability Study of the Medical Information Device #1 (MIND1) in Subjects With Schizophrenia or Bipolar I Disorder
• Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
• Safety and Tolerability Study of Aripiprazole IM Depot in Adult Subjects With Schizophrenia
• A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation
• Phase 3 Study of Ataluren in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD)
• Safety, Tolerability, and Pharmacokinetic Study of EVP-6124 in Patients With Schizophrenia
• IVIG Treatment for Refractory Immune-Related Adult Epilepsy
• Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy
• Effect of Autonomic Neuropathy on the Efficacy of a DPP-IV Inhibitor (Galvus) Therapy
• Dexmedetomidine in Patients After Intracranial Surgery
• Clinical Trial of Brain-Penetrating HIV Drugs to Prevent Cognitive Impairment in China
• Study to Assess Droxidopa in the Treatment of Freezing Of Gait Symptoms in Patients With Parkinson's Disease
• Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU)
• Dysport® Adult Upper Limb Spasticity Extension Study
• Dysport® Adult Upper Limb Spasticity
• Intra-Erythrocyte Dexamethasone Sodium Phosphate in Ataxia Teleangiectasia Patients
• Safety and Efficacy Evaluation of DOTAREM® in MRI of Central Nervous System (CNS) Lesions
• Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis
• Study of Memantine for Gait Disorders And Attention Deficit In Parkinson's Disease
• Safety and Cognitive Function Study of EVP-6124 in Patients With Mild to Moderate Alzheimer's Disease
• Safety and Cognitive Function Study of EVP-6124 in Patients With Schizophrenia
• Triheptanoin Treatment Trial for Patients With Adult Polyglucosan Body Disease
• Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease (PARKGAIT-II)
• Study of Ranexa in Patients With Coronary Artery Disease and Painful Polyneuropathy
• DNX-2401 (Formerly Known as Delta-24-RGD-4C) for Recurrent Malignant Gliomas
• Safety, Tolerability, and Pharmacokinetic Study of EVP-6124 in Patients With Alzheimer's Disease
• The Pathophysiology of Orthostatic Hypotension
• Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases
• Safety and Efficacy of Gadobutrol 1.0 Molar (Gadavist) in Patients for Central Nervous System (CNS) Imaging
• MR, Histologic And EM Imaging Of Intravenous Ferumoxytol In Central Nervous System (CNS) Inflammation
• A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases
• Safety and Efficacy of Gadobutrol 1.0 Molar ( Gadavist ) in Patients for Central Nervous System (CNS) Imaging
• Treatment of Orthostatic Hypotension
• Augmenting Effects of L-DOPS With Carbidopa and Entacapone
• Follow Up Safety Study of SCH 420814 in Subjects With Parkinson's Disease (P05175)
• Effects of Coenzyme Q10 in PSP and CBD
• Fluid Retention in Rosiglitazone Treated Subjects With Autonomic Neuropathy.
• Dyskinesia in Parkinson's Disease (Study P04501)
• Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases
• Efficacy and Safety Study to Evaluate Gadavist (Gadobutrol) as Contrast Agent in Magnetic Resonance Imaging (MRI) of Brain or Spine Diseases in Chinese Patients
• Study to Evaluate Eye Function in Patients Taking Linezolid for Six Weeks or Greater
• Dietary Supplements for the Treatment of Angelman Syndrome
• Safety and Efficacy of MultiHance in Pediatric Patients
• Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy
• A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic's Disease)
• Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
• Safety and Efficacy Study of Prosaptide to Treat Neuropathic Pain in HIV-Positive Patients
• A Follow-up Study to Assess Safety and Tolerability of Galantamine Treatment in Individuals With Mild Cognitive Impairment
• Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy (HIV-AN) or Postherpetic Neuralgia (PHN)
• Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
• Dose-Finding Study of REN-1654 in Patients With Post-Herpetic Neuralgia
• An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain
• Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy
• Tolerability of Three Local Anesthetic Formulations in Conjunction With NGX-4010 for the Treatment of Neuropathic Pain
• Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
• Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy
• NGX-4010 for the Treatment of Postherpetic Neuralgia
• Cerebril™ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy
• Acetyl-L-Carnitine for the Treatment of NRTI-Associated Peripheral Neuropathy
• Marijuana for HIV-Related Peripheral Neuropathy
• Neotrofin for Treatment of Chemotherapy-Induced Peripheral Neuropathy
• Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain
• Oregon Center for Complementary and Alternative Medicine in Neurological Disorders
• Phase I/II Study of Human Anti-Cytomegalovirus (CMV) Monoclonal Antibody MSL-109 in Newborns With Symptomatic Congenital CMV Infection Without Central Nervous System Disease
• Intranasal Peptide T in the Treatment of Painful Peripheral Neuropathy of AIDS
• Positron Emission Tomography to Measure Pain and Pain Control
• A Phase I/II Pilot Treatment Study Of CSF Penetration And Response To Ganciclovir And Foscarnet In CMV Neurologic Disease.
• A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy
• The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients
• A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection