The Role of Intestinal Flora in the Pathogenesis of FD and the Intervention of Xiangsha Liujunzi
Status:
Recruiting
Trial end date:
2022-08-30
Target enrollment:
Participant gender:
Summary
Functional dyspepsia (FD) is a common digestive system disease in clinic. Although it has not
reached the level of life-threatening, it seriously affects the quality of life of patients.
The pathogenesis of FD mainly involves gastric motility disorder and visceral
hypersensitivity. At present, there are gastric motility promoting drugs and gastric acid
inhibiting drugs, but they can not achieve satisfactory therapeutic effect. Traditional
Chinese medicine has a good clinical effect on FD, but the specific mechanism is not clear.
With the gradual deepening of intestinal flora research, it provides a useful tool for
elucidating the mechanism of action of traditional Chinese medicine compound. The role of
intestinal flora in the pathogenesis of FD, especially in the pathogenesis of symptoms, has
not been studied, and the mechanism of Spleen-strengthening and motility-promoting effects of
Xiangsha Liujun has not been studied from the perspective of intestinal flora. In this study,
16S rRNA high-throughput sequencing technology was used to observe the difference of
intestinal flora between FD patients and normal people, and then to observe the effect of
Xiangsha Liujun on intestinal flora of FD patients. The aim of this study was to explore the
role of intestinal flora in the pathogenesis of FD and to elucidate the therapeutic mechanism
of Xiangsha Liujunzi by regulating intestinal flora of FD patients, so as to provide support
for follow-up clinical and experimental studies.
Phase:
N/A
Details
Lead Sponsor:
Xiyuan Hospital of China Academy of Chinese Medical Sciences