The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)
Status:
Not yet recruiting
Trial end date:
2024-07-31
Target enrollment:
Participant gender:
Summary
There is a lack of complex studies which could establish the association between genetic
circadian factors with the features and short-term outcomes of ischemic stroke, as well as
the effects of various auxiliary therapies for circadian rhythm modulation for
neuroplasticity enhancement and improvement of short-term outcomes in ischemic stroke.
The main research hypothesis is that circadian factors influence the recovery from ischemic
stroke via sleep-mediated regulation of synaptic plasticity.
The project aims at the investigation of the influence of combined melatonin therapy and blue
light exposure on molecular circadian biomarkers, sleep characteristics, neuroplasticity
markers and stroke outcome in acute stroke patients.
This study is a prospective, interventional, randomized placebo-controlled trial.
Phase:
Phase 4
Details
Lead Sponsor:
Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health