The Impact of Rosiglitazone on Regression of Atherosclerosis
Status:
Suspended
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Cardiovascular events are the leading cause of death in developed countries worldwide,
including Taiwan. The disruption of atherosclerotic plaques and the subsequent formation of
thrombi are currently recognized as the major cause of morbidity and mortality of
cardiovascular diseases. Therefore, early detection of vulnerable plaques is clinically
important for risk stratification and also to provide early treatment. Several imaging
approaches have been adapted to detect vulnerable plaques, however, most of them are based on
morphologic characteristics of atheroma. We hypothesize that PPARĪ³-induced plaque regression
could be monitored clinically by use of 18FDG PET/CT approach, which could assess the
inflammatory activity, and can be detected noninvasively earlier than previously reported.