Overview
The Efficacy of Adjuvant Chemotherapy in Locally Advanced Cervical Cancer
Status:
Recruiting
Recruiting
Trial end date:
2028-04-01
2028-04-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
The aim of this trial was to evaluate the efficacy of adjuvant chemotherapy in the locally advanced cervical cancer with residual lesions after concurrent chemoradiation therapy.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Chongqing University Cancer HospitalTreatments:
Cisplatin
Paclitaxel
Criteria
Inclusion Criteria:1. Cervical cancer stage IIb to IVa with a histopathology of squamous cell carcinoma,
adenosquamous cell carcinoma, adenocarcinoma
2. Complete CCRT(Radiation Does: A point 85Gy(+/-10%),B点50Gy(+/-10%),concurrent
paclitaxel and cisplatin once a week for six cycles)
3. MRI is performed within 4 weeks after CCRT and shows residual lesions (non-lymph
node≥10mm,lymph node shortest diameter≥15mm).
4. ECOG<2
5. Expected survival is longer than six months
6. Hb≥70g/L、WBC≥3.5×109/ L 、ANC≥1.5×109/L、PLT≥80×109/L
7. ALT and AST≤2×ULN, Serum creatinine≤1.5×ULN
8. The serum or urine pregnancy test must be negative within 7 days before enrollment for
the women of childbearing age who should agree that contraception must be used during
the trial
Exclusion Criteria:
1. Activity or uncontrol severe infection
2. Liver cirrhosis, Decompensated liver disease
3. History of immune deficiency, including HIV positive or suffering from congenital
immunodeficiency disease
4. Patients who cannot tolerate chemotherapy because of chronic renal insufficiency or
renal failure
5. Have suffered or combined with other malignant tumor
6. Myocardial infarction, severe arrhythmia and NYHA (New York heart association)≥2 for
congestive heart failure
7. A history targeted therapy or pelvic artery embolization
8. Artery-enous thrombosis within 6 months
9. Patients with autoimmune diseases
10. Complications, need to be treatment with drugs which may lead to liver or kidney
injury
11. Patients with disease progression after chemoradiation