To see if ranitidine, by reducing stomach acidity, can enhance the effectiveness of
foscarnet, by making foscarnet more available to the body.
Foscarnet is an antiviral compound. Laboratory studies have shown it to be active against
HIV. However, only 12 - 22 percent of an oral foscarnet dose is absorbed by the body.
Ranitidine suppresses gastric acid output, increasing gastric pH. Thus by increasing gastric
pH (decreasing stomach acidity), less foscarnet is expected to be decomposed or broken down
in the stomach. Thus, more foscarnet should be absorbed into the body.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)